Regulation of hemidesmosome dynamics and cell signaling by integrin α6β4

L Te Molder, JM de Pereda… - Journal of Cell …, 2021 - journals.biologists.com
… In this Review, we detail the role of α6β4 in HD assembly … During wound healing and in
psoriatic lesions, the … which the availability of integrins at the cell surface can be regulated. …

[HTML][HTML] Hemidesmosomes modulate force generation via focal adhesions

W Wang, A Zuidema, L Te Molder, L Nahidiazar… - Journal of Cell …, 2020 - rupress.org
… β4 concentrated in type I HD clusters along the ventral surface. These … At the early stage
of wound healing, dissolved HDs can be … , integrin α6β4 was shown to move into assembling

[PDF][PDF] Mechano-transduction mediated b integrin-based adhesion complexes: integration of c toskeleton and adhesion d namics

W Wang - 2022 - scholarlypublications …
… that keratinocytes lacking hemidesmosomal integrin α6β4 exhibit … , integrin α6β4 was shown
to move into assembling … cytoplasmic variants of the integrin alpha 6 subunit in transfected …

The basement membrane in epidermal polarity, stemness, and regeneration

P Rousselle, C Laigle… - American Journal of …, 2022 - journals.physiology.org
… they leave the basal layer and move upward toward the surface, where they die and slough
… -332, hemidesmosomes assemble through the interaction of the β4 integrin cytoplasmic tail …

[HTML][HTML] Adenovirus-mediated LAMA3 transduction enhances hemidesmosome formation and periodontal reattachment during wound healing

Y Li, J Zhang, Z Cheng, Y Wang, T Huang, K Lai… - … Therapy Methods & …, 2020 - cell.com
… attached to the tooth surface through the hemidesmosome (HD) … The integral colocalized
linear structure of integrin β4 and … α 3 chain subunit in hemidesmosome stability and assembly. …

[HTML][HTML] Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

Y Liu, C Ho, D Wen, J Sun, L Huang, Y Gao, Q Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
… transmembrane protein constituting hemidesmosomes (HDs)… move to the suprabasal
epidermis and eventually to the skin … substrate-attached surface by binding to α6β4 integrin 79 . A …

[HTML][HTML] Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

NG Fischer, C Aparicio - Bioactive materials, 2022 - Elsevier
… JE is formation of hemidesmosomes, cell/matrix … hemidesmosomes and their five main
components. The authors highlight the known (and unknown) effects dental implant – as a model

[HTML][HTML] Syndecans and their synstatins: targeting an organizer of receptor tyrosine kinase signaling at the cell-matrix interface

AC Rapraeger - Frontiers in Oncology, 2021 - frontiersin.org
… requires the RTK and integrin to be assembled into a functional unit [… in highly stable
hemidesmosomes, the α6β4 integrin is … Displacement of paxillin also inhibits the cross-talk …

Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function

BJ Goggins, K Minahan, S Sherwin… - American Journal …, 2021 - journals.physiology.org
… and migrate by the rapid assembly and disassembly of focal … , however, hemidesmosome
structures disassemble in … expression to prevent functional displacement of integrins α2 and α6…

[HTML][HTML] Interplay between cell-surface receptors and extracellular matrix in skin

S Kleiser, A Nyström - Biomolecules, 2020 - mdpi.com
… of integrin β4 and thereby stabilizes hemidesmosomes [59]. … matrix crosstalks would foster
a move from descriptive studies … Alpha 6 beta 4 integrin and newly deposited laminin-1 and …